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polycarbonateurethane surface with poly(ethylene glycol) monoacrylate and phosphorylcholine glyceraldehyde for anti-plateletadhesion

Jing YANG,Juan LV,Bin GAO,Li ZHANG,Dazhi YANG,Changcan SHI,Jintang GUO,Wenzhong LI,Yakai FENG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 2,   Pages 188-196 doi: 10.1007/s11705-014-1414-1

Abstract: Poly(ethylene glycol) monoacrylate (PEGMA) is grafted onto polycarbonateurethane (PCU) surface via ultraviolet initiated photopolymerization. The hydroxyl groups of poly(PEGMA) on the surface react with one NCO group of isophorone diisocyanate (IPDI) and another NCO group of IPDI is then hydrolyzed to form amino terminal group, which is further grafted with phosphorylcholine glyceraldehyde to establish a biocompatible hydrophilic structure on the surface. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy confirm the successful grafting of both PEG and phosphorylcholine functional groups on the surface. The decrease of the water contact angle for the modified film is caused by synergic effect of PEG and phosphorylcholine, which both have the high hydrophilicity. Furthermore, the number of platelets adhered is relative low on the synergetically modified PCU film compared with the PCU film modified only by poly(PEGMA). Our synergic modification method using both PEG and phosphorylcholine may be applied in surface modification of blood-contacting biomaterials and some relevant devices.

Keywords： poly(ethylene glycol) monoacrylate     phosphorylcholine     polycarbonateurethane     surface modification     anti-plateletadhesion     biomaterials    

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Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via two

Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 76-84 doi: 10.1007/s11684-015-0426-7

Abstract:

Anti-β2 glycoprotein I (anti-β2GP I ) antibodies are importantβ2GP I as mediators of platelet activation, which can serve as a potential source contributinginvolvement of the apolipoprotein E receptor 2' (apoER2') and glycoprotein I ba (GP I bα) in plateletPlatelet activation was assessed by measuring GP II b/ III a activation and P-selectin expression andResults showed that the anti-β2GP I /β2GP I complex induced platelet

Keywords： anti-β2GP I /β2GP I complex     platelet     GP I bα     apoER2'     thrombosis    

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Anti-β2GPI/β2GPI complexes induce platelet activation and promote thrombosis via

Wenjing Zhang, Caijun Zha, Xiumin Lu, Ruichun Jia, Fei Gao, Qi Sun, Meili Jin, Yanhong Liu

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 680-689 doi: 10.1007/s11684-018-0673-5

Abstract: Anti- glycoprotein I (anti- GPI) antibodies are important contributors to the development of thrombosisAnti- GPI antibody complexes with GPI are well known to activate monocytes and endothelial cells viaBy contrast, the interaction of anti- GPI/ GPI complexes with platelets has not been extensively studiedFurthermore, SB203580 inhibits anti- GPI/ GPI complex-induced platelet activation.Thrombus formation decreased in mice after treatment with anti- GPI/ GPI complexes.

Keywords： anti-   

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Abivertinib inhibits megakaryocyte differentiation and platelet biogenesis

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 416-428 doi: 10.1007/s11684-021-0838-5

Abstract: of megakaryopoiesis, we speculate that abivertinib can affect megakaryocyte (MK) differentiation and plateletobserved megakaryopoiesis to determine the biological effect of abivertinib on MK differentiation and plateletWe also demonstrated in vivo that abivertinib decreased the number of MKs in bone marrow and plateletthese preclinical data collectively suggested that abivertinib could inhibit MK differentiation and platelet

Keywords： abivertinib     Btk inhibitor     platelet     megakaryocyte     megakaryopoiesis     thrombopoiesis    

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Materials and surface engineering to control bacterial adhesion and biofilm formation: A review of recent

Huan GU, Dacheng REN

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 1,   Pages 20-33 doi: 10.1007/s11705-014-1412-3

Abstract: Bacterial adhesion to surfaces and subsequent biofilm formation are a leading cause of chronic infections

Keywords： surface engineering     materials     bacterial adhesion     biofilm     control     review    

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Platelet-rich plasma: combinational treatment modalities for musculoskeletal conditions

Isabel Andia, Michele Abate

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 139-152 doi: 10.1007/s11684-017-0551-6

Abstract: Platelet-rich plasma therapies have emerged as a potential approach to enhance tissue repair and regenerationPlatelet-rich plasma application aims to provide supraphysiological concentrations of platelets and optionallyHowever, the efficacy of platelet-rich plasma is controversial in chronic diseases because patients&rsquoIn this review, the interactions between platelet-rich plasma and healing mechanisms were addressed andThe development of combinational platelet-rich plasma treatments that can be used safely and effectively

Keywords： regenerative medicine     joint conditions     muscle injuries     platelet rich plasma     tendinopathy     healing mechanisms    

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Engineering platelet-mimicking drug delivery vehicles

Quanyin Hu, Hunter N. Bomba, Zhen Gu

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 624-632 doi: 10.1007/s11705-017-1614-6

Abstract: Recreating the specific biological features of platelets by mimicking the structure of the platelet ortranslocating the platelet membrane to synthetic particles holds great promise in disease treatment.This review highlights recent advancements made in the platelet-mimicking strategies.

Keywords： drug delivery     platelets     nanomedicine     bio-inspired     biomimetic    

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Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy

Yinlong Zhang, Guangna Liu, Jingyan Wei, Guangjun Nie

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 667-677 doi: 10.1007/s11684-017-0583-y

Abstract: understanding of the role of platelets in cancer progression and metastasis provides promising approaches for plateletbiomimetic drug delivery systems and functional platelet-targeting strategies for effective cancer treatmentThis review highlights recent progresses in platelet membrane-based drug delivery and unique strategies

Keywords： platelet-mimicking delivery systems     tumor-associated platelets     cancer therapy     EPR effect    

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On the applicability of different adhesion models in adhesive particulate flows

Guanqing LIU, Shuiqing LI, Qiang YAO,

Frontiers in Energy 2010, Volume 4, Issue 2,   Pages 280-286 doi: 10.1007/s11708-009-0062-5

Abstract: An adhesion map provides quantitative criteria for the appropriate selection of adhesion models applicableIn this paper, three different general adhesion models are used to construct adhesion maps.The applicable regimes on the adhesion map for different approximate adhesion models are determined accordingIt is found that the choice of general model has limited influence on the structure of a constructed adhesionA three-dimensional, more intuitive adhesion map based on physical parameters of particles is also built

Keywords： adhesive contact     van der Waals force     adhesion model     adhesion map     DEM    

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The relationship between platelet-derived growth factor expression and angiogenesis/lymphangiogenesis

Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 447-451 doi: 10.1007/s11684-009-0082-x

Abstract: This paper is aimed to examine if changes in platelet-derived growth factor (PDGF) expression at different

Keywords： cervical cancer     lymphatic vessel density     blood vessel density     platelet-derived growth factor    

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Effect of interface adhesion factor on the bearing capacity of strip footing placed on cohesive soil

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 6,   Pages 1494-1503 doi: 10.1007/s11709-021-0768-y

Abstract: By considering the different values of interface adhesion factor (αcr) between the

Keywords： bearing capacity     soil-rock interface     Hoek−Brown yield criterion     plasticity     limit analysis    

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Study on the cohesion and adhesion of hot-poured crack sealants

Meng GUO, Yiqiu TAN, Xuesong DU, Zhaofeng LV

Frontiers of Structural and Civil Engineering 2017, Volume 11, Issue 3,   Pages 353-359 doi: 10.1007/s11709-017-0400-3

Abstract: The cohesion and adhesion of crack sealant directly determine its service performance and durability.However, the competitive mechanism of cohesion and adhesion failure modes is not clear currently.This research proposed two methods to evaluate cohesion and adhesion of crack sealant, and analyzed theinfluence of temperature on cohesion and adhesion.There is a critical temperature at which the cohesion force equals the adhesion force.

Keywords： crack sealant     concrete pavement     cohesion     adhesion     moisture damage    

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CD176 single-chain variable antibody fragment inhibits the adhesion of cancer cells to endothelial cells

Jiangnan Liu,Bin Yi,Zhe Zhang,Yi Cao

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 204-211 doi: 10.1007/s11684-016-0443-1

Abstract: glycotope) functionally involved in blood spread and liver metastasis of cancer cells by mediating the adhesionFurthermore, the CD176 scFv inhibits the adhesion of CD176+ cancer cells to endothelial

Keywords： CD176     Thomsen-Friedenreich antigen     scFv     cancer     therapy     adhesion     metastasis    

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QUANTITATIVE STUDY ON ANTI-PEST ACTIVITY OF NATURAL PRODUCTS BASED ON VISUALIZATION FRAMEWORK OF KNOWLEDGE

Frontiers of Agricultural Science and Engineering 2023, Volume 10, Issue 2,   Pages 306-332 doi: 10.15302/J-FASE-2023488

Abstract:

● Using visual analysis to predict the trend of natural product pest resistance.

Keywords： anti-pest activity     crop protection     insect pest     natural product     visual analysis    

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protein on PVDF ultrafiltration membrane fouling behavior under different pH conditions: interface adhesion

Xudong WANG,Miao ZHOU,Xiaorong MENG,Lei WANG,Danxi HUANG

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 4, doi: 10.1007/s11783-016-0855-9

Abstract: Dramatic flux decline is caused by membrane–BSA adhesion force at start of filtration.range of pH values, self-made atomic force microscopy (AFM) colloidal probes were used to detect the adhesionResults showed that the membrane–BSA adhesion interaction was stronger than the BSA–BSA adhesion interactionPVDF/PVP membranes, which indicated that the fouling was mainly caused by the adhesion interaction betweenAt the same pH condition, the PVDF/PVA membrane–BSA adhesion force was smaller than that of PVDF/PVP

Keywords： PVDF membrane     Membrane fouling     Adhesion force     Protein     Interfacial free energy    

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Title Author Date Type Operation

polycarbonateurethane surface with poly(ethylene glycol) monoacrylate and phosphorylcholine glyceraldehyde for anti-plateletadhesion

Jing YANG,Juan LV,Bin GAO,Li ZHANG,Dazhi YANG,Changcan SHI,Jintang GUO,Wenzhong LI,Yakai FENG

Journal Article

Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via two

Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu

Journal Article

Anti-β2GPI/β2GPI complexes induce platelet activation and promote thrombosis via

Wenjing Zhang, Caijun Zha, Xiumin Lu, Ruichun Jia, Fei Gao, Qi Sun, Meili Jin, Yanhong Liu

Journal Article

Abivertinib inhibits megakaryocyte differentiation and platelet biogenesis

Journal Article

Materials and surface engineering to control bacterial adhesion and biofilm formation: A review of recent

Huan GU, Dacheng REN

Journal Article

Platelet-rich plasma: combinational treatment modalities for musculoskeletal conditions

Isabel Andia, Michele Abate

Journal Article

Engineering platelet-mimicking drug delivery vehicles

Quanyin Hu, Hunter N. Bomba, Zhen Gu

Journal Article

Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy

Yinlong Zhang, Guangna Liu, Jingyan Wei, Guangjun Nie

Journal Article

On the applicability of different adhesion models in adhesive particulate flows

Guanqing LIU, Shuiqing LI, Qiang YAO,

Journal Article

The relationship between platelet-derived growth factor expression and angiogenesis/lymphangiogenesis

Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,

Journal Article

Effect of interface adhesion factor on the bearing capacity of strip footing placed on cohesive soil

Journal Article

Study on the cohesion and adhesion of hot-poured crack sealants

Meng GUO, Yiqiu TAN, Xuesong DU, Zhaofeng LV

Journal Article

CD176 single-chain variable antibody fragment inhibits the adhesion of cancer cells to endothelial cells

Jiangnan Liu,Bin Yi,Zhe Zhang,Yi Cao

Journal Article

QUANTITATIVE STUDY ON ANTI-PEST ACTIVITY OF NATURAL PRODUCTS BASED ON VISUALIZATION FRAMEWORK OF KNOWLEDGE

Journal Article

protein on PVDF ultrafiltration membrane fouling behavior under different pH conditions: interface adhesion

Xudong WANG,Miao ZHOU,Xiaorong MENG,Lei WANG,Danxi HUANG

Journal Article